Author

Michael Lofgren

University of Michigan

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Biophysics· 1

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aaron M. Keller· 1 shared Ace George SantiagoiD· 1 shared Guangjie YaniD· 1 shared Manhua Pan· 1 shared Peng Chen· 1 shared Ruma V. BanerjeeiD· 1 shared Tai‐Yen CheniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Aaron M. Keller

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1 paper

Recent·Most cited

Conformation-gated binding drives negative cooperativity in ATP:cob(I)alamin Adenosyltransferase for optimized cobalamin handling

Guangjie Yan, Manhua Pan, Aaron M. Keller, Ace George Santiago, Michael Lofgren, Ruma V. Banerjee, Peng Chen, Tai‐Yen Chen

This study identifies conformation-gated binding as the mechanism driving negative cooperativity in ATP:cob(I)alamin adenosyltransferase (MMAB), optimizing cobalamin handling and preventing resource waste.

bioRxiv · Jan 7, 2025 · PreprintBiophysics