Author

Peng Chen

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biophysics· 2 Neuroscience· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Aaron M. Keller· 1 shared Aaron W. McGeeiD· 1 shared Ace George SantiagoiD· 1 shared Bifeng Liu· 1 shared Bo WangiD· 1 shared Chenghao Zhai· 1 shared Chenglong LuoiD· 1 shared Chong Li· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperBiophysics

Aaron M. Keller

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Author profile →

6 papers

Recent·Most cited

Neuropil aggrecan, not perineuronal nets, closes the critical period for visual plasticity

Emily C. Crouse, Thomas C. Brown, Xiaokuang Ma, Hongtao Ma, Kylee Karpowich, Kieran Barber, Peng Chen, Shenfeng Qiu, Aaron W. McGee

This study shows that aggrecan in excitatory neurons, not perineuronal nets, limits visual plasticity by closing the critical period in adult mice.

bioRxiv · Aug 22, 2026 · PreprintNeuroscience

Multi-layered molecular regulation of complex traits in an advanced intercross line

Xiaoning Zhu, Chenghao Zhai, Chong Li, Rongrong Liu, Hongmei Mou, Yunfei Zhu, Wei Luo, Peng Chen, Hanyu Wu, Yuzhan Wang, Kai Shi, Mian Gong, Weijie Zheng, Jian Ji, Chenglong Luo, , Yuzhe Wang

The paper maps a multi-layered molecular QTL atlas in chicken to understand complex trait regulation across tissues and developmental stages.

bioRxiv · Aug 21, 2026 · PreprintGenetics

A Novel Central-Peripheral Interface: The Auditory Nerve Glial Transition Zone Exhibits Enhanced Age-Related Immune and Glial Cell Dysfunction

Shelby A. Payne, Haley R Anderson, Isaac M. Brown, Jiaxin Chai, Peng Chen, Hai Yao, Jeremy L. Barth, Hainan Lang

This study identifies the auditory nerve glial transition zone as a critical site of age-related immune and glial dysfunction contributing to hearing loss.

Frontiers in Immunology · Aug 7, 2026Peer-reviewedNeuroscience

Accelerating antibiotic discovery from Earth's isolated habitats through protein language models and microfluidics

Zixin Kang, Haohong Zhang, Qize Zhou, Jiayi Liu, Kouyi Zhou, Peng Chen, Bifeng Liu, Kang Ning

The paper develops MicroSPEAR, a framework combining a protein language model and microfluidics to discover and validate antimicrobial peptides from isolated habitats.

bioRxiv · Nov 13, 2025 · PreprintBioinformatics

A Palette of Bridged Bicycle-Strengthened Fluorophores

Junwei Zhang, Kecheng Zhang, Kui Wang, Bo Wang, Siyan Zhu, Hongping Qian, Yumiao Ma, Mengling Zhang, Tianyan Liu, Peng Chen, Yuan Shen, Yunzhe Fu, Shilin Fang, Xinxin Zhang, Peng Zou, , Zhixing Chen

This paper introduces a new class of fluorophores with enhanced photostability, solubility, and tunable properties for advanced biological imaging applications.

Nature Methods · May 19, 2025Peer-reviewedBiophysics

Conformation-gated binding drives negative cooperativity in ATP:cob(I)alamin Adenosyltransferase for optimized cobalamin handling

Guangjie Yan, Manhua Pan, Aaron M. Keller, Ace George Santiago, Michael Lofgren, Ruma V. Banerjee, Peng Chen, Tai‐Yen Chen

This study identifies conformation-gated binding as the mechanism driving negative cooperativity in ATP:cob(I)alamin adenosyltransferase (MMAB), optimizing cobalamin handling and preventing resource waste.

bioRxiv · Jan 7, 2025 · PreprintBiophysics