NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion
Michael S. Dahabieh, Lisa M. DeCamp, Brandon M. Oswald, Susan M. Kitchen-Goosen, Zhen Fang Fu, Matthew Vos, Shelby E. Compton, Joseph Longo, Nicole M Foy, Kelsey S. Williams, Abigail E. Ellis, Amy Jo Johnson, Ibukunoluwa Sodiya, Michael Vincent, Hyoungjoo Lee, , Russell G. Jones
This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.
Nature Immunology · Jun 27, 2025Peer-reviewedImmunology