Zhen Fang Fu

The paper shows that maternal SETDB1 is essential for silencing 2-cell totipotency genes in mouse embryos, allowing development beyond the 8-cell stage.

The paper develops a chimeric vaccine platform that delivers self-assembling particles, triggering strong lung immunity and broad virus protection across species.

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

This study identifies YAP signaling as a driver of resistance to MEK and AKT inhibitors in NF1-related MPNSTs using preclinical models and spatial transcriptomics.

This study identifies TRIM72 as a host factor that restricts lyssavirus infection by promoting ubiquitination and proteasomal degradation of the viral matrix protein.

The paper develops MiP-Seq, a multiomics in situ sequencing method, to analyze spatial gene profiles, mutations, and RNA modifications at single-cell resolution.

The paper develops a multi-fluorescent rabies virus tracing tool to map corticothalamic projection neuron subsets in the primary visual cortex, revealing their layer-specific distribution and multi-target connectivity.