Total body irradiation primes CD19-directed CAR T cells against large B-cell lymphoma
Mohammad Alhomoud, Michelle Foley, Mayumi Sugita, Joshua Alexander Fein, Samuel Yamshon, Leandro Marcelo Martinez, Kai Rejeski, Maider Astorkia, Doron Betel, Renier J. Brentjens, Koen van Besien, Lorenzo Galluzzi, Olivier Boyer, J. Martinet, Silvia Chiara Formenti, Mónica L. Guzmán
This study shows that total body irradiation before CAR T cell infusion enhances their effectiveness against large B-cell lymphoma by improving cytotoxicity and survival outcomes.
bioRxiv · Mar 17, 2025 · PreprintCancer Biology