Author

Michelle Simon

Mary Lyon Centre at MRC Harwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ann‐Marie MalloniD· 2 shared Elizabeth FisheriD· 2 shared Simon Greenaway· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Aitana Perea-GómeziD· 1 shared Alasdair J. AllaniD· 1 shared Alejo Torres-CanoiD· 1 shared Alessandra VigilanteiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersGenetics

Ann‐Marie MallonORCID

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5 papers

Recent·Most cited

Mesodermal-niche interactions direct specification and differentiation of pancreatic endocrine cells in human multilineage organoids

Georgina Goss, Alejo Torres-Cano, Raquel A. Martínez García de la Torre, Siwanarta Ma, Leila Hermosilla Andrivet, Michelle Simon, Martina Pedna, Heather Wilson, Flavia Flaviani, Alessandra Vigilante, Francesca M. Spagnoli

The paper demonstrates that mesoderm-derived cells in organoids promote endocrine commitment and β-cell differentiation in human pancreatic development.

bioRxiv · Oct 12, 2026 · PreprintDevelopmental Biology

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

Chloé Mayère, Violaine Regard, Aitana Perea-Gómez, Corey Bunce, Yasmine Neirijnck, Cyril Djari, Natividad Bellido-Carreras, Pauline Sararols, Richard Reeves, Simon Greenaway, Michelle Simon, Pam Siggers, Diana Condrea, Françoise Kühne, Ivana Gantar, , Serge Nef

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

Science Advances · May 25, 2022Peer-reviewedDevelopmental Biology

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down Syndrome-related phenotypes

Eva Lana‐Elola, Heather L. Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, , Victor L. J. Tybulewicz

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

Disease Models & Mechanisms · Sep 6, 2021Peer-reviewedGenetics

Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS

Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie K. A. Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair J. Allan, Gemma F. Codner, R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero‐Gagliardi, José Miguel Brito Armas, , Thomas J. Cunningham

The paper creates genomically humanised knock-in mice for ALS/FTD genes SOD1, TARDBP, and FUS, showing they express human proteins at endogenous levels and are phenotypically normal.

bioRxiv · Jul 5, 2021 · PreprintNeuroscience

Tolerance of nonsynonymous variation is closely correlated between human and mouse orthologues

George Powell, Michelle Simon, Sara L. Pulit, Ann‐Marie Mallon, Cecilia M. Lindgren

The paper estimates intraspecific constraint for mouse genes and shows strong correlation with human orthologues, linking constraint to pleiotropy and Mendelian disease.

bioRxiv · Jun 3, 2019 · PreprintGenomics