Cheryl L. Scudamore

This study shows that a specific PTEN mutation causes macrocephaly, lymphoid overgrowth, and late-onset cancer in mice by impairing nuclear PTEN functions, while maintaining normal PI3K/AKT signaling.

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

This paper develops hypoxia-sensing CAR T-cells that selectively target solid tumors without off-tumor toxicity using murine xenograft models.

The paper reports on the occurrence of tarsal injuries in male C57BL/6N mice across multiple international facilities, describing clinical signs and findings from radiographic and histological analyses.