Author

Mike Costa

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jean‐Philippe FortiniD· 2 shared Marinella G. CallowiD· 2 shared Scott E. MartiniD· 2 shared Aaron T. L. LuniD· 1 shared Aditya MurthyiD· 1 shared Anne SpangiD· 1 shared Ariane Nissenbaum· 1 shared Benjamin HaleyiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Jean‐Philippe FortinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity

Liza Malong, Jessica Roskosch, Carolina Hager, Jean‐Philippe Fortin, Roland Schmucki, Marinella G. Callow, Christian Weile, Valentina Romeo, Christoph Patsch, Scott E. Martin, Mike Costa, Zora D. Modrusan, Roberto Villaseñor, Erich Koller, Benjamin Haley, , Filip Roudnicky

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

Nature Communications · Jun 30, 2025Peer-reviewedCell Biology

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

Simone M. Haag, Shiqi Xie, Céline Eidenschenk, Jean‐Philippe Fortin, Marinella G. Callow, Mike Costa, Aaron T. L. Lun, Chris Cox, Sunny Z. Wu, Rachana Pradhan, Jaclyn Y. Lock, Julia Kuhn, Loryn L. Holokai, Minh Thai, Emily C. Freund, , Aditya Murthy

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

Nature Genetics · Oct 23, 2024Peer-reviewedImmunology

Seed sequences mediate off-target activity in the CRISPR-interference (CRISPRi) system

Neha Rohatgi, JP Fortin, Ted Lau, Yi Ying, Yue Zhang, Mike Costa, Rohit Reja

The paper investigates off-target activity in CRISPRi by analyzing a genome-wide sgRNA library and finds that seed sequences mediate most off-target effects.

bioRxiv · Apr 10, 2024 · PreprintBioinformatics