Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification
Simone M. Haag, Shiqi Xie, Céline Eidenschenk, Jean‐Philippe Fortin, Marinella G. Callow, Mike Costa, Aaron T. L. Lun, Chris Cox, Sunny Z. Wu, Rachana Pradhan, Jaclyn Y. Lock, Julia Kuhn, Loryn L. Holokai, Minh Thai, Emily C. Freund, , Aditya Murthy
The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.
Nature Genetics · Oct 23, 2024Peer-reviewedImmunology