Elastase mediated white matter damage in cerebral small vessel disease: Microglia - neutrophils pas de deux
Cheng-Ya Dong, Weiqi Chen, Qi Li, Junwan Fan, Tian Lan, Wanlin Dong, Lina Sun, Yingjie Wang, Mingming Shi, Yongjin Huang, Yingying Chang, Ningning Wang, Jing Xue, Lingling Jiang, Yue Ming Huang, , Wei-Na Jin
This study identifies elastase (ELANE) as a driver of white matter damage in cerebral small vessel disease, showing its role in oligodendrocyte death and proposing it as a therapeutic target.
bioRxiv · Dec 23, 2024 · PreprintNeuroscience