Genomic profiling of young-onset gBRCA1/2 breast cancer reveals distinct genomic landscapes and therapeutic implications for PARP and CDK4/6 inhibitor selection
Mwangala P. Akamandisa, Mingyi Xia, Wilson Cheah, Bradley Stephen Wubbenhorst, Kurt P D'Andrea, Mengyao Fan, Jake S. Shilan, Dana Pueschl, Anupma Nayak, Hayley McKenzie, William Tapper, Ellen Copson, Ramsey Cutress, Susan M. Domchek, Diana Eccles, Katherine L. Nathanson
This study compares genomic features of gBRCA1 and gBRCA2 breast cancers, finding distinct mutational patterns and therapeutic implications for PARP and CDK4/6 inhibitors.
medRxiv · Sep 19, 2025 · PreprintGenetic & Genomic Medicine