Author

MinQi Lu

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

David B. FrankiD· 4 shared Lisa R. YoungiD· 4 shared Prashant ChandrasekaraniD· 4 shared Sylvia N. MichkiiD· 3 shared Edward CantuiD· 2 shared Edward E. MorriseyiD· 2 shared Hannah Hallquist· 2 shared Hongbo WeniD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersDevelopmental Biology

David B. FrankORCID

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4 papers

Recent·Most cited

A Single-Cell Atlas of PVOD Across the Lifespan Reveals Cellular and Molecular Therapeutic Targets

Prashant Chandrasekaran, Sylvia N. Michki, Jennifer E. Pogoriler, Quinn Wright, MinQi Lu, Andrew R. Peterson, Hannah Hallquist, Edward Cantu, Edward E. Morrisey, Lisa R. Young, Maria Ciocca Basil, Susan M. Lin, David B. Frank

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

bioRxiv · Oct 14, 2026 · PreprintMolecular Biology

A postnatal human lung developmental atlas reveals windows of genetic vulnerability to chronic lung disease

Joseph D. Planer, Michael P. Morley, Songlin Cai, Andrew R. Peterson, MinQi Lu, Yifan Yang, Hannah Hallquist, Sarah E. Schaefer, Justine Carl, Su Zhou, Susan M. Lin, Prashant Chandrasekaran, Lisa R. Young, Edward Cantu, William H. Peranteau, , Maria Ciocca Basil

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

bioRxiv · Mar 24, 2026 · PreprintDevelopmental Biology

Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development

Derek C. Liberti, Hongbo Wen, Kwaku K. Quansah, Prashant Chandrasekaran, Josh Pankin, Sylvia N. Michki, Annabelle Jin, MinQi Lu, Maureen Peers de Nieuwburgh, Lisa R. Young, Rajan Jain, David B. Frank

This study shows that BRD4 in endodermal cells is crucial for lung development by facilitating epithelial-mesenchymal crosstalk, proper lineage allocation, and branching morphogenesis.

bioRxiv · May 21, 2023 · PreprintDevelopmental Biology

A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth

Prashant Chandrasekaran, Nicholas M. Negretti, Aravind Sivakumar, Maureen Peers de Nieuwburgh, Joanna Wang, Sylvia N. Michki, Fatima N. Chaudhry, Hongbo Wen, Sukhmani Kaur, MinQi Lu, Jarod A. Zepp, Lisa R. Young, Jennifer M. S. Sucre, David B. Frank

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.

bioRxiv · Apr 30, 2022 · PreprintDevelopmental Biology