Hanna Barlit

This study shows that manipulating heme levels in yeast extends lifespan, independent of Hap4, and reveals a link between heme homeostasis and aging.

The paper uses ribosome profiling to show how iron deficiency affects protein translation in yeast by altering gene expression and RNA-binding protein activity.

The paper shows that reducing Cth2 activity in yeast increases lifespan by improving mitochondrial function through reduced repression of iron-related genes.