Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay
Divya Kolakada, Rui Fu, Nikita Biziaev, Alexey V. Shuvalov, Mlana Lore, Amy E. Campbell, Michael A. Cortázar, Marcin Piotr Sajek, Jay R. Hesselberth, Neelanjan Mukherjee, Elena Z. Alkalaeva, Zeynep Coban‐Akdemir, Sujatha Jagannathan
The paper identifies the amino acid preceding a premature termination codon as a key determinant of nonsense-mediated mRNA decay efficiency.
Cell Genomics · May 19, 2025Peer-reviewedMolecular Biology