Marcin Piotr Sajek

Fatty Acid Synthase Binds Cellular mRNAs and its Depletion Reduces Translational Efficiency

This study identifies FASN's RNA binding sites and shows its depletion reduces translational efficiency of associated mRNAs.

Isoform-Specific Localization Diversifies Human MSI2 Function

This study identifies alternative splicing as a mechanism determining MSI2 subcellular localization and regulatory function, showing isoform-specific effects on translation and nuclear processes.

Nanopore sequencing of intact aminoacylated tRNAs

This paper introduces a method to simultaneously measure tRNA sequence, modification, and aminoacylation using nanopore sequencing and machine learning.

Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay

The paper identifies the amino acid preceding a premature termination codon as a key determinant of nonsense-mediated mRNA decay efficiency.

PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

This study shows PDGFRα signaling regulates Srsf3 binding to transcripts, affecting PI3K signaling and endosomal trafficking in craniofacial development.

Circular RNA - circCLIP2 is predominantly expressed in GSC niche and enhances glioblastoma aggressiveness via EMT and ECM signaling

This study identifies circCLIP2 as a circRNA overexpressed in glioblastoma stem cells that promotes tumor aggressiveness through EMT and ECM signaling.

Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes

The paper identifies a small molecule inhibitor that targets multiple RNA binding proteins, showing its effects are independent of Musashi-2 and provides a framework for validating RBP inhibitor specificity.

RNAlign2D, a novel RNA structural alignment tool based on pseudo-amino acid substitution matrix

RNAlign2D rapidly aligns RNA sequences by converting them to pseudo-amino acids and using MUSCLE, producing accurate alignments for RNA classification and function prediction.

A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of GADD45A, GADD45B, GADD45G and RHOB genes

The paper identifies a NANOS1 mutation that switches its function from anti-apoptotic to pro-apoptotic in human germ cells by disrupting repression of pro-apoptotic genes.

Human PUM1 and PUM2 exhibit regulation of divergent mRNA targets in male germ cells

The paper identifies distinct mRNA targets and protein cofactors regulated by PUM1 and PUM2 in human male germ cells, revealing functional divergence in their RNA regulatory roles.

Kinesin KIF18A is a novel PUM regulated target promoting mitotic progression and survival of human male germ cell line - TCam-2

This study identifies KIF18A as a PUM-regulated gene that promotes proliferation and survival in human male germ cell line TCam-2 cells.

Deciphering human ribonucleoprotein regulatory networks

The paper analyzes RBP-RNA interactions across 64 RBPs to identify regulatory modules and their functional roles in RNA metabolism and localization.