Jay R. Hesselberth

The paper develops a bioinformatic pipeline using small serine recombinases to identify antiphage defense systems in bacterial genomes and metagenomes, finding they are genetically linked to these systems.

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

This paper identifies ASOs that correct cryptic exon inclusion in SDCCAG8, restoring protein expression in BBS patients.

The paper identifies a unique transcriptional program in lymphatic endothelial cells that predicts antigen archiving capacity and validates it across datasets and in vivo.

This paper introduces a method to simultaneously measure tRNA sequence, modification, and aminoacylation using nanopore sequencing and machine learning.

The paper investigates how Big1 regulates cell size by controlling basal body number through cell cycle progression in Tetrahymena.

The paper identifies the amino acid preceding a premature termination codon as a key determinant of nonsense-mediated mRNA decay efficiency.

The paper identifies unique phenotypic and BCR repertoire features of pancreatic islet antigen-reactive B cells in prediabetic and recent-onset type 1 diabetes individuals compared to non-diabetic donors.

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

This study demonstrates the use of updated nanopore sequencing to characterize 43 RNA modifications in tRNAs, including mitochondrial and viral tRNAs, and provides best practices for future research.

This study shows CHIKV infection disrupts lymph node lymphatic endothelial cell composition and function through MARCO interactions, leading to impaired antigen acquisition and increased inflammation.

The paper introduces scraps, a pipeline for high-resolution APA detection in scRNA-seq, showing it outperforms existing methods and enables assessment of internal priming events.

The paper identifies unique nanopore sequencing signals from 2'-phosphorylated RNAs, enabling detection of RNA repair events in yeast.

This paper highlights the issue of insufficient metadata in scRNA-seq studies, hindering data reuse and reproducibility, and advocates for improved documentation standards.

clustifyr assigns cell types to scRNA-seq clusters using diverse reference data and provides tools for exploratory analysis.

The paper shows that multiple decay events regulate HAC1 mRNA splicing and the UPR in budding yeast by modulating degradation of splicing intermediates.

The paper develops a method to recover and analyze targeted transcriptome subsets from scRNA-seq libraries, improving sequencing depth and gene detection.

The paper quantifies A-to-I RNA editing in hibernating ground squirrels and finds cold-induced editing sites that may provide neuroprotection during torpor.

The paper describes using Segway software to annotate genomes with chromatin data from ChIP-seq experiments, providing a semi-automated workflow for interpretation.