The mevalonate pathway couples lipid metabolism to amino acid synthesis via ubiquinone-dependent redox control
Thi Thinh Nguyen, Mohit Bansal, Jane Ding, Sunil Sudarshan, Han‐Fei Ding
This study shows the mevalonate pathway supports amino acid synthesis by promoting mitochondrial NAD regeneration through ubiquinone-dependent electron transport, and statin inhibition disrupts this process.
bioRxiv · Aug 10, 2025 · PreprintCancer Biology