Cancer BiologybioRxivPreprint
The mevalonate pathway couples lipid metabolism to amino acid synthesis via ubiquinone-dependent redox control
Thi Thinh Nguyen, Mohit Bansal, Jane Ding…·Han‐Fei Ding
This study shows the mevalonate pathway supports amino acid synthesis by promoting mitochondrial NAD regeneration through ubiquinone-dependent electron transport, and statin inhibition disrupts this process.
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