Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging
C. Yong, D. Moose, N. Bannick, M. Vanneste, R. Svensson, P. Breheny, J. Brown, M. Cohen, M. Henry
The paper improves a prostate cancer mouse model with a bioluminescent reporter to monitor tumor progression and shows that double knockout of Pten and Trp53 leads to castrate-resistant, locally invasive tumors.
bioRxiv · Apr 23, 2020Cancer Biology