Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
E. R. Hantz, S. B. Tikunova, N. Belevych, J. P. Davis, P. J. Reiser, S. Lindert
The paper investigates small molecules targeting troponin C to enhance calcium sensitivity in cardiac and skeletal muscle without altering systolic calcium levels, identifying a potent sensitizer with an apparent affinity of 117 ± 17 M.
bioRxiv · Feb 6, 2023Biochemistry