BiochemistrybioRxiv
Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship
E. R. Hantz, S. B. Tikunova, N. Belevych…·S. Lindert
The paper investigates small molecules targeting troponin C to enhance calcium sensitivity in cardiac and skeletal muscle without altering systolic calcium levels, identifying a potent sensitizer with an apparent affinity of 117 ± 17 M.
DOI 10.1021/acs.jcim.3c00196