Author

N. Bruiners

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

M. L. Gennaro· 2 shared C. Markosian· 1 shared D. Davis· 1 shared D. I. Staquicini· 1 shared E. C. Lattime· 1 shared E. Dodero Rojas· 1 shared F. H. F. Tang· 1 shared F. I. Staquicini· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

M. L. Gennaro

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Design and proof-of-concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain

D. I. Staquicini, F. H. F. Tang, C. Markosian, V. J. Yao, F. I. Staquicini, E. Dodero Rojas, V. G. Contessoto, D. Davis, P. O'Brien, N. Habib, T. L. Smith, N. Bruiners, R. L. Sidman, M. L. Gennaro, E. C. Lattime, , R. Pasqualini

This paper designs and evaluates phage-based and AAVP-based vaccination strategies for SARS-CoV-2 that induce systemic antibody responses in mice, with potential for a cold-free supply chain.

bioRxiv · Mar 15, 2021Microbiology

The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis

N. Bruiners, N. K. Dutta, V. Guerrini, H. Salamon, K. Yamaguchi, P. Karakousis, M. L. Gennaro

This study shows simvastatin's anti-tubercular effect is due to cholesterol inhibition, which activates AMPK, blocks mTORC1, and promotes TFEB-driven autophagy.

bioRxiv · Mar 4, 2020Immunology