ImmunologybioRxiv
The anti-tubercular activity of simvastatin is mediated by cholesterol-dependent regulation of autophagy via the AMPK-mTORC1-TFEB axis
N. Bruiners, N. K. Dutta, V. Guerrini…·M. L. Gennaro
This study shows simvastatin's anti-tubercular effect is due to cholesterol inhibition, which activates AMPK, blocks mTORC1, and promotes TFEB-driven autophagy.
DOI 10.1194/jlr.ra120000895