Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational design
N. Codina, C. Zhang, N. Chakroun, P. Dalby
This paper uses molecular dynamics and computational design to analyze the stability of a therapeutic antibody Fab fragment under low pH and high temperature, identifying key regions for stabilization.
bioRxiv · May 20, 2019 · PreprintBiophysics