C. Zhang

Marker-specific pixel attribution for single-cell protein quantification with PixAQ

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial Dysfunction

The paper identifies RBBP6-mediated degradation of JUNB as a mechanism causing 3D enhancer-promoter disruption and endothelial dysfunction in diabetes.

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast Cancers

The paper shows that combining anti-CSF-1R therapy with chemotherapy and anti-PD-1 improves immune response in metastatic TNBC by reducing macrophages and increasing T/B cell infiltration.

PyEvoCell: An LLM- Augmented Single Cell Trajectory Analysis Dashboard

PyEvoCell uses an LLM to aid in interpreting single-cell trajectory analysis by suggesting lineages, performing differential expression analysis, and validating hypotheses with PubMed citations.

Unraveling MLL1-fusion Leukemia: Epigenetic Revelations from an iPS Cell Point Mutation

This study introduces a point mutation in MLL1 in iPS cells to mimic MLL1F-LSCs phenotypes, revealing that loss of MLL1 enzymatic activity drives H3K4 trimethylation via mislocalized SETd1a.

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

Shrimp Hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation

This study shows shrimp hemocyanin (SHC) can replace keyhole limpet hemocyanin (KLH) as a carrier protein for hapten conjugation, offering better solubility and comparable immunogenicity in mammals.

Role of Kir4.1/Kir5.1 in mediating Angiotensin-II (Ang-II)-induced stimulation of thiazide-sensitive Na-Cl cotransporter.

This study investigates how Ang-II affects NCC through Kir4.1/Kir5.1 in the DCT, finding that short-term effects depend on Kir4.1/Kir5.1, while long-term effects are independent.

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

Diversified global vegetable oil production can mitigate climate change and achieve socio-environmental co-benefits

This paper assesses the environmental and economic impacts of global vegetable oil production and shows that diversification can reduce emissions and increase farmer income.

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

This study uses a protein language model to discover new phosphorus-cycling protein families in deep-sea cold seep sediments, revealing novel microbial processes and ecological roles.

Blebs regulate phosphoinositides distribution and promote cell survival through the Septin-SH3KBP1-PI3K axis

The paper shows blebs regulate phosphoinositides distribution via the Septin-SH3KBP1-PI3K axis, promoting cell survival during anoikis resistance.

Oncogenic NOVA1 expression dysregulates alternative splicing in breast cancer

This study shows that NOVA1 overexpression in breast cancer disrupts alternative splicing, particularly in genes related to cell communication and cytoskeleton, and is linked to worse outcomes in Luminal A tumors.

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Deep mutational scanning reveals sequence to function constraints for SWEET family transporters

This study uses deep mutational scanning to analyze sequence-function relationships in the plant SWEET transporter AtSWEET13, identifying mutations that enhance transport function and revealing constraints in transmembrane helix 4.

Loss of neurofibromin accelerates uveal and dermal melanoma formation driven by GNAQ

This study shows that Nf1 loss accelerates melanoma formation in mice with GNAQ mutations, highlighting cAMP signaling and its link to MMNSTs.

Digital pathology assessment of kidney glomerular filtration barrier ultrastructure in an animal model of podocytopathy

This paper develops a deep learning method to automate measurement of glomerular basement membrane and podocyte foot process widths in TEM images of podocytopathy mouse models, showing comparable accuracy to manual methods.

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer's disease

This study identifies axonal enlargement linked to amyloidosis, lysosome destabilization, and hemorrhage as a key pathological feature in Alzheimer's disease.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

Rapid evolution of fine-scale recombination during domestication: a perspective from population genomics

The paper constructs a fine-scale recombination map in domestic chickens to study rapid evolutionary changes in recombination rates during domestication.

An orphan viral genome with controversial evolutionary status sheds light on a distinct lineage of flavi-like virus infecting plants

This study resolves the taxonomic controversy of SRAV, a plant-infecting flavi-like virus, by showing it belongs to the Flaviviridae family and triggers host RNAi responses.

Tibetan terrestrial and aquatic ecosystems collapsed with cryosphere loss inferred from sedimentary ancient metagenomics

This paper uses ancient metagenomics and network analysis to show that cryosphere loss over 18,000 years drove ecosystem shifts in the Tibetan Plateau, refuting top-down herbivore control and highlighting keystone plant species.

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

This study identifies PDE1A as a promoter of NSCLC metastasis through interaction with YTHDF2 and activation of the STAT3 pathway.

IP3R1 is required for meiotic progression and embryonic development by regulating mitochondrial calcium and oxidative damage

This study shows that IP3R1 knockdown in porcine oocytes disrupts ER-mitochondria calcium signaling, leading to oxidative stress and impaired meiotic progression and embryonic development.

Molecular basis for the host range function of the poxvirus PKR inhibitor E3

This paper identifies species-specific interactions between poxvirus PKR inhibitors E3 and K3 and host PKR proteins, challenging the sequestration model for E3 function.

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

In vivo evaluation of thermally drawn biodegradable optical fibers as brain neural interfaces

This study evaluates biodegradable PDLLA optical fibers as neural interfaces in mice, showing degradation and efficient SW-NIR light transmission with potential for optogenetics and therapy.