Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
C. A. Nichols, W. J. Gibson, M. S. Brown, J. A. Kosmicki, J. P. Busanovich, H. Wei, L. M. Urbanski, N. Curimjee, A. C. Berger, G. F. Gao, A. D. Cherniack, S. Dhe-Paganon, B. R. Paolella, R. Beroukhim
The paper identifies LOH of essential genes as a class of non-driver cancer vulnerabilities by showing allele-specific inactivation can selectively kill cancer cells.
bioRxiv · Jan 29, 2019Cancer Biology