G. F. Gao

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

This study compares the immune evasion of SARS-CoV-2 Omicron BA.2.86 to XBB sub-variants, finding BA.2.86 shows less neutralization evasion.

This study evaluates the neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from vaccinated individuals and breakthrough infections, finding that next-generation vaccines offer better protection against these variants.

This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study evaluates the neutralization of SARS-CoV-2 501Y.V2 variant by antisera from two Chinese vaccines, showing preserved neutralizing titres against the variant.

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

The paper determines the near-atomic structure of the SARS-CoV-2 polymerase complex and shows reduced activity and thermostability compared to SARS-CoV.

The paper identifies LOH of essential genes as a class of non-driver cancer vulnerabilities by showing allele-specific inactivation can selectively kill cancer cells.