H. Wei

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation

The O-Fucosyltransferase SPINDLY Attenuates Auxin-Induced Fruit Growth by Inhibiting ARF6 and ARF8 binding to Coactivator Mediator Complex in Arabidopsis

This study shows that SPINDLY-mediated O-fucosylation of ARF6 and ARF8 inhibits their interaction with the coactivator Mediator complex, reducing fruit growth in Arabidopsis.

Targeting Tuberculosis: Novel Scaffolds for Inhibiting Cytochrome bd Oxidase

This study identifies six new cytochrome bd inhibitor scaffolds through computational screening and validates their activity against Mycobacterium tuberculosis.

Overexpression of Alpha-1 Antitrypsin Increases the Proliferation of Mesenchymal Stem Cells by Upregulation of Cyclin D1 and is Independent of the Wnt Signaling Pathway

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

Chemical inhibition of PIN auxin transporters by the anti-inflammatory drug Naproxen

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

Fully Automated Multi-Grid Cryo-EM Screening using Smart Leginon

Smart Leginon automates cryo-EM grid screening, reducing operator time from 6 hours to <10 minutes and improving throughput.

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical use

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

A flexible, efficient, and scalable platform to produce circular RNAs as new therapeutics

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

Deconstructing cold-induced brown adipocyte neogenesis in mice

The paper identifies ASC1 as direct precursors of brown adipocytes and shows that immune cell recruitment and b3-adrenergic receptor activation drive cold-induced neogenesis in mice.

A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, Fabrication, and Physiological relevancy

This paper presents an in-vitro hydraulic setup modeling the atrioventricular-aortic system to study hemodynamic interactions and physiological parameters.

Oral administration of bacterial Beta cell expansion factor A (BefA) alleviates diabetes in mice with Type 1 and Type 2 diabetes

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

Present and Future Ecological Niche Modeling of Rift Valley fever in East Africa in Response to Climate Change

This study models the future distribution of Rift Valley fever in East Africa under climate change scenarios using MaxEnt, identifying key environmental factors and predicting expanded disease spread.

Bacterium-Enabled Transient Gene Activation by Artificial Transcription Factor for Resolving Gene Regulation in Maize

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

Long noncoding RNA VENTHEART is required for cardiomyocyte specification and function

This study identifies VENTHEART as a lncRNA essential for cardiomyocyte specification, maturation, and function, with potential relevance to heart disease.

Data-informed discovery of hydrolytic nanozymes

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

Time-resolved cryoEM using Spotiton

The paper introduces a method for preparing cryoEM grids to study short-lived molecular states by rapidly dispensing sample drops and vitrifying them.

Plant DNA polymerases alpha and delta mediate replication of geminiviruses

This study identifies DNA polymerases alpha and delta as key mediators of geminivirus replication in plants, with C3 protein selectively recruiting polymerase delta for efficient viral genome synthesis.

Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9

This paper improves HDR efficiency for gene knock-in in poplar by combining XRCC4 silencing with CtIP and MRE11 overexpression, achieving higher knock-in rates and fewer InDels.

Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wild Cicer spp. under aluminium stress

The paper identifies and analyzes MATE transporter genes in wild chickpea species under aluminum stress, finding that CaMATE2 is upregulated in all lines while CaMATE1 is upregulated in most, correlating with root growth responses.

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: a new avenue for glioma tumour surveillance

This study uses SWATH-MS to comprehensively profile plasma extracellular vesicles from glioma patients, identifying potential biomarkers that reflect glioma subtype and aggressiveness.

Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.