Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
R. Gasser, M. Cloutier, J. Prevost, C. Fink, E. Ducas, S. Ding, N. Dussault, P. Landry, T. Tremblay, A. Laforce-Lavoie, A. Lewin, G. Beaudoin-Bussieres, A. Laumaea, H. Medjahed, C. Larochelle, , A. Finzi
This study shows that IgM plays a major role in neutralizing SARS-CoV-2 in convalescent plasma, with its depletion causing the greatest loss of neutralizing activity.
bioRxiv · Oct 9, 2020Microbiology