S. Ding

The neonatal Fc receptor and DPP4 are human astrovirus receptors

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Effect of Circadian Rhythm Modulated Blood Flow on Nanoparticle based Targeted Drug Delivery in Virtual In Vivo Arterial Geometries

This paper develops a computational model to simulate nanoparticle drug delivery in virtual arterial geometries, showing that circadian rhythm modulated blood flow and vessel geometry affect drug adhesion and retention.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

African Swine Fever Virus Protein B263R Inhibits Autophagy by Promoting Proteasomal Degradation of Beclin1

This study identifies B263R as an ASFV protein that inhibits autophagy by promoting proteasomal degradation of Beclin1, highlighting its role in viral replication and potential therapeutic targets.

Coupled metalipidomics-metagenomics reveal structurally diverse sphingolipids produced by a wide variety of marine bacteria

The paper uses metalipidomics and metagenomics to identify structurally diverse sphingolipids produced by marine bacteria in the Black Sea, revealing novel lipid species and expanded bacterial synthesis capabilities.

Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission

This study examines how temperature affects Spike-ACE2 interactions in Omicron subvariants and links these interactions to viral transmission efficiency.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

Selective lipid recruitment by an archaeal DPANN symbiont from its host

This study identifies 110 lipid species selectively recruited by an archaeal DPANN symbiont from its host, revealing changes in lipid composition and membrane fluidity.

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus.

This study develops a human air-liquid interface culture system for Cryptosporidium hominis, revealing it induces type III interferon and reduces Rotavirus infectivity.

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

Differences in spore size and atmospheric survival shape stark contrasts in the dispersal dynamics of two closely related fungal pathogens

This study compares the atmospheric survival and dispersal dynamics of two fungal pathogens, showing that smaller spores survive longer and disperse farther despite being less durable.

Anthracyclines inhibit SARS-CoV-2 infection

This study identifies anthracyclines as potential SARS-CoV-2 inhibitors through a microbial metabolite screening effort, showing they inhibit viral infection via different mechanisms.

High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot

The paper sequences and assembles the nuclear and mitochondrial genomes of Bipolaris sorokiniana strain LK93 to improve understanding of its interaction with wheat.

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection

This study identifies four broad, potent monoclonal antibodies against SARS-CoV-2 spike protein that neutralize multiple variants, including Omicron and XBB.1.5, targeting conserved regions with high functional constraint.

Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target

This study identifies calpain-2 as a host factor facilitating SARS-CoV-2 entry and shows calpain inhibitors inhibit viral infection through an Mpro-independent pathway.

Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells

This study identifies RNF213 as essential for IFN-gamma-mediated restriction of intracellular pathogens like Toxoplasma gondii and Mycobacterium tuberculosis through ubiquitination, independent of autophagy.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile

Mucosal and systemic neutralizing antibodies to norovirus and rotavirus by oral immunization with recombinant rotavirus in infant mice

This paper demonstrates that oral immunization with a recombinant rotavirus expressing norovirus VP1 induces systemic and mucosal neutralizing antibodies against both rotavirus and norovirus in infant mice.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter

The paper shows SERINC3 has a structure similar to lipid transporters and demonstrates its lipid flipping activity, which correlates with reduced HIV-1 infectivity.

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues

This study examines tRNA transcriptomes and translatomes in mouse tissues to explore their relationship with translational efficiency and tissue-specific proteomes.

SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cells

This study investigates the infection of human colon epithelial cells by the SARS-CoV-2 Omicron BA.1 variant, finding it infects similarly or less effectively than the ancestral strain and Delta variant.

A recombinant murine rotavirus with Nano-Luciferase expression reveals tissue tropism, replication dynamics, and virus transmission

This paper develops a recombinant murine rotavirus expressing Nano-Luciferase to study tissue tropism, replication dynamics, and transmission in vivo.

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

Comparative analysis of cattle breeds as satellite cell donors for cultured beef

The paper compares SC proliferation and differentiation across cattle breeds to identify optimal donors for cultured beef production.