Structure of the antidiuretic hormone vasopressin receptor signalling complex.
J. Bous, H. Orcel, N. Floquet, C. Leyrat, J. Lai-Kee-Him, G. Gaibelet, A. Ancelin, J. Saint-Paul, S. Trapani, M. Louet, R. Sounier, H. Demene, S. Granier, P. Bron, B. Mouillac
The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.
bioRxiv · Dec 22, 2020 · PreprintBiochemistry