Author

H. Orcel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

B. Mouillac· 3 shared R. Sounier· 3 shared S. Granier· 3 shared A. Fouillen· 2 shared G. Gaibelet· 2 shared H. Demene· 2 shared J. Bous· 2 shared J. Saint-Paul· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

B. Mouillac

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Author profile →

3 papers

Recent·Most cited

Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

G. Gaibelet, A. Fouillen, R. Stephanie, H. Orcel, C. Mendre, A. Kanso, R. Lanotte, J. Nguyen, J. Dimon, S. Urbach, R. Sounier, S. Granier, D. Bonnet, X. Cong, B. Mouillac, H. Demene

The paper uses NMR, molecular dynamics, and pharmacology to study conformational changes in the V2R receptor bound to different ligands, revealing a mechanism for Gs-biased agonism involving TM7 and TM3 interactions.

bioRxiv · Jun 6, 2023 · PreprintBiophysics

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

J. Bous, A. Fouillen, H. Orcel, S. Trapani, X. Cong, S. Fontanel, J. Saint-Paul, J. LAI KEE HIM, S. Urbach, N. Sibille, R. SOUNIER, S. Granier, B. Mouillac, P. Bron

The paper reports the cryo-EM structure of the V2 receptor-{beta}-arrestin1 complex, revealing structural variability in GPCR-arrestin interactions.

bioRxiv · Feb 11, 2022Biochemistry

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

J. Bous, H. Orcel, N. Floquet, C. Leyrat, J. Lai-Kee-Him, G. Gaibelet, A. Ancelin, J. Saint-Paul, S. Trapani, M. Louet, R. Sounier, H. Demene, S. Granier, P. Bron, B. Mouillac

The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.

bioRxiv · Dec 22, 2020 · PreprintBiochemistry