Author

N. Frazao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Gordo· 5 shared A. Konrad· 1 shared A. Sousa· 1 shared D. Guleresi· 1 shared D. Güleresi· 1 shared E. Seixas· 1 shared H. Barreto· 1 shared M. Lassig· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersEvolutionary Biology

I. Gordo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Massive lateral gene transfer under strain coexistence in the gut

N. Frazao, E. Seixas, H. Barreto, M. Mischler, D. Guleresi, I. Gordo

The paper studies how two distinct E. coli strains coexist in the mouse gut and finds strain-specific evolutionary modes and significant lateral gene transfer.

bioRxiv · Sep 25, 2023 · PreprintEvolutionary Biology

Shared evolutionary path in social microbiomes

N. Frazao, I. Gordo

The paper assesses how host-to-host bacterial transmission affects E. coli evolution in mice, finding a daily transmission rate of 7% and similar evolutionary dynamics among co-housed mice.

bioRxiv · Feb 7, 2023Evolutionary Biology

Two modes of evolution shape bacterial strain diversity in the gut for thousands of generations

N. Frazao, A. Konrad, D. Güleresi, M. Lässig, I. Gordo

This study shows that two evolutionary modes shape bacterial strain diversity in the gut over thousands of generations, with diversifying selection leading to ecotype coexistence and directional selection causing selective sweeps.

bioRxiv · Jan 11, 2022Evolutionary Biology

DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance

R. Balbontin, N. Frazao, I. Gordo

The paper shows that targeting RNase HI, which degrades R-loops causing DNA breaks, increases the fitness cost of antibiotic resistance and can eliminate resistant bacteria.

bioRxiv · Feb 3, 2020Microbiology

Sex overrides mutation in Escherichia coli colonizing the gut

N. Frazao, A. Sousa, M. Lassig, I. Gordo

The paper shows that phages drive rapid evolution in the gut by promoting horizontal gene transfer and genetic diversity in E. coli.

bioRxiv · Aug 7, 2018Evolutionary Biology