M. Lässig

This paper models B-cell antigen recognition during acute infections, showing it follows a generalized Luria-Delbruck process with power-law statistics and highlights the impact of aging on immune response.

This study shows vaccination influences SARS-CoV-2 antigenic evolution by analyzing sequence data, epidemiology, and neutralization assays to model evolutionary dynamics.

This study shows that two evolutionary modes shape bacterial strain diversity in the gut over thousands of generations, with diversifying selection leading to ecotype coexistence and directional selection causing selective sweeps.

This study shows how molecular recognition sites can evolve to complex states by adapting to moving targets, increasing code length and reducing coding density through an adaptive ratchet mechanism.

The paper develops a fitness model to predict antibiotic resistance evolution by linking metabolic effects to growth rates and resistance levels in E. coli.

The paper develops a fitness model to analyze eco-evolutionary control of pathogens, showing how control strategies depend on mutation rates and population size.