Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors
M. B. Mumphrey, N. Hosseini, A. Parolia, J. Geng, W. Zou, M. Raghavan, A. Chinnaiyan, M. Cieslik
The paper identifies distinct mutational processes in MHC class I and II genes across primary and metastatic tumors, showing positive selection for mutations disrupting immune interfaces and linking them to immune checkpoint inhibitor response.
bioRxiv · Jan 22, 2023Cancer Biology