W. Zou

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

The Multifaceted Effects of Short-Term Acute Hypoxia Stress: Insights into the tolerance mechanism of Propsilocerus akamusi (Diptera: Chironomidae)

This study investigates how P. akamusi tolerates acute hypoxia through multi-omics analysis, revealing metabolic and enzymatic adaptations that support its survival in eutrophic lakes.

A Single Site Mutation Tunes Fluorescence and Chromophorylation of an Orange Fluorescent Cyanobacteriochrome

The paper improves PEB chromophorylation in GAF3 by a single mutation and plasmid modifications, enhancing fluorescence and tuning emission.

Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy

This paper develops automated tumor immunophenotyping pipelines to predict clinical benefit from anti-PD-L1 therapy in NSCLC and TNBC patients.

Avirulent ME49Δgra5 Protecting Hosts Against Toxoplasma gondii Infection and Breast Tumors

This paper shows that the gra5 knockout T. gondii strain ME49Δgra5 is avirulent, prevents cyst formation, and protects against T. gondii infection and breast tumor growth in mice.

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

The paper identifies distinct mutational processes in MHC class I and II genes across primary and metastatic tumors, showing positive selection for mutations disrupting immune interfaces and linking them to immune checkpoint inhibitor response.

Arabidopsis ORP2A positively regulates glucose signaling by interacting with AtRGS1 and promoting AtRGS1 degradation

Enhancing Mitochondrial Functions by Optogenetic Clustering

This paper develops an optogenetic method to control mitochondrial clustering and shows it enhances mitochondrial functions.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

The Transcriptome Architecture of Polyomaviruses

The paper characterizes the transcriptome architecture of polyomaviruses using RNA sequencing data, revealing pervasive wraparound transcription and novel conserved transcripts.

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

The SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia

This study examines the SARS-CoV-2 transcriptome in human airway epithelia, identifying frequent deletions at the S1/S2 boundary and their dynamics in virions.

Control of archetype BK polyomavirus miRNA expression

The paper investigates how BK polyomavirus miRNA expression is regulated, showing that miRNA is expressed from introns of circular primary transcripts that circle the genome multiple times.

An endoplasmic reticulum (ER) ATPase safeguards ER identity by removing ectopically localized mitochondrial proteins

This study identifies CATP-8 as an ER-localized P5A ATPase that removes mislocalized mitochondrial proteins from the ER, preserving ER identity and function.

Relationship Between Neuroendocrine and Immune Gene Expression in Small Cell Lung Cancer

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

Glucose Production and Glucose Disposal Integrated by an Intrinsic Inverse Coupling in Vivo: hypothesis of inter-organ reflex on glucose regulation

The paper demonstrates that glucose production and disposal are inversely coupled in vivo, regardless of insulin target site, and shows this coupling persists despite metabolic challenges.

Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

ASK1/p38-mediated NLRP3 inflammasome signaling pathway contributed to aberrant retinal angiogenesis in diabetic retinopathy

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

Gfi1-expressing Paneth cells revert to stem cells following intestinal injury

This study shows that Gfi1-expressing secretory cells can revert to stem cells after intestinal injury, with PI3kinase/AKT and WNT signaling enhancing this process.