J. Geng

Internet-connected cortical organoids for project-based stem cell and neuroscience education

This paper describes using internet-connected cortical organoids to enhance STEM education through project-based learning in two university courses.

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

The paper identifies distinct mutational processes in MHC class I and II genes across primary and metastatic tumors, showing positive selection for mutations disrupting immune interfaces and linking them to immune checkpoint inhibitor response.

ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasis

Internet of Things Architecture for Cellular Biology

The paper develops an IoT architecture to control biological devices in experiments, enabling real-time monitoring and automation through a unified web interface.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

Total Biosynthesis of Triacsin Featuring an N-hydroxytriazene Pharmacophore

This study identifies the enzymes responsible for biosynthesizing the N-hydroxytriazene pharmacophore in triacsins, revealing two ATP-dependent enzymes involved in consecutive N-N bond formation.

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions

This study identifies how mutated calreticulin (CRTDel52) forms dimers stabilized by disulfide bonds and ionic interactions, leading to Mpl activation and cytokine-independent cell proliferation in MPNs.

Controlled-release urea combined with potassium chloride improved the soil fertility and growth of Italian ryegrass

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

Global Profiling of 2-hydroxyisobutyrylome in Common Wheat

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

Identifying the Biosynthetic Gene Cluster for Triacsins with an N-hydroxytriazene Moiety

This study identifies the biosynthetic gene cluster for triacsins in Streptomyces aureofaciens and discovers a new producer species.