Conformational ensembles of the human intrinsically disordered proteome: Bridging chain compaction with function and sequence conservation
G. Tesei, A. I. Trolle, N. Jonsson, J. Betz, F. Pesce, K. E. Johansson, K. Lindorff-Larsen
The paper develops a model to predict conformational ensembles of human intrinsically disordered regions (IDRs) from sequence, showing correlations between chain compaction, function, localization, and sequence conservation across orthologs.
bioRxiv · May 8, 2023 · PreprintBiophysics