A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth
J. L. Gillis, J. A. Hinneh, N. K. Ryan, S. Irani, M. Moldovan, R. K. Shrestha, L.-E. Quek, A. J. Hoy, J. Holst, M. M. Centenera, I. G. Mills, D. J. Lynn, L. A. Selth, L. M. Butler
This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.
bioRxiv · Sep 2, 2020Cancer Biology