A. J. Hoy

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.

This study shows ACC1 drives breast cancer progression through lipogenesis, with ACC1 knockout reducing tumor growth and altering lipid profiles in both mouse models and human cells.

This study identifies distinct lipid droplet proteome changes in mice fed high-fat or high-starch diets compared to chow, linking these changes to fatty liver and glucose tolerance.

This study identifies ACSM1 and ACSM3 as AR-regulated factors that promote prostate cancer growth by enhancing fatty acid metabolism and suppressing ferroptosis.

This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.