Cancer BiologybioRxivPreprint
The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics
W. Giblin, L. Bringman-Rodenbarger, A. H. Guo…·D. B. Lombard
This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.
DOI 10.1101/2020.09.07.286526