Author

A. L. Osterman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Arabidopsis· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. E. Zlamal· 2 shared M. Elane· 2 shared M. Vercruysse· 2 shared S. A. Leyn· 2 shared A. A. Arzamasov· 1 shared A. Andea· 1 shared A. C. Monovich· 1 shared A. H. Guo· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

J. E. Zlamal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens

S. A. Leyn, J. E. Kent, J. E. Zlamal, M. Elane, M. Vercruysse, A. L. Osterman

This study uses experimental evolution and whole genome sequencing to compare resistance mechanisms to GP6 and ciprofloxacin in E. coli and A. baumannii, finding distinct evolutionary trajectories dominated by efflux pump upregulation for GP6.

bioRxiv · Jun 26, 2023 · PreprintMicrobiology

Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagR

A. A. Arzamasov, A. Nakajima, M. Sakanaka, M. N. Ojima, T. Katayama, D. A. Rodionov, A. L. Osterman

This study identifies NagR as a global transcriptional regulator governing HMO utilization pathways in B. infantis, revealing its role in regulating multiple HMO catabolic pathways and evolutionary adaptation.

bioRxiv · Apr 6, 2022Microbiology

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-negative Bacterial Pathogens

J. E. Zlamal, S. A. Leyn, M. Iyer, M. Elane, N. A. Wong, J. W. Wamsley, M. Vercruysse, F. Garcia-Alcalde, A. L. Osterman

This study uses a comparative resistomics approach to analyze the evolutionary trajectories of ciprofloxacin resistance in three Gram-negative bacteria, revealing shared and species-specific resistance mechanisms.

bioRxiv · Apr 6, 2021Microbiology

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

bioRxiv · Sep 7, 2020 · PreprintCancer Biology