D. B. Lombard

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload

This study shows that overexpressing SIRT5 protects against cardiac dysfunction and fibrosis in response to pressure overload in mice.

Canagliflozin increases adenoma burden in female APCMin/+ mice

This study shows that canagliflozin increases adenoma burden in female APCMin/+ mice, suggesting complex, cell-non-autonomous mechanisms and sex differences in drug effects.

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice

This study shows canagliflozin extends lifespan in male but not female mice, likely by reducing peak glucose levels, similar to acarbose.

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance

This study identifies small molecules that induce cellular stress resistance against paraquat, cadmium, and methyl methanesulfonate, with some compounds activating Nrf2 signaling and others triggering inflammatory and AMPK pathways.