Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis in an ER stress-dependent manner.
B. A. Martinez, S. Yeudall, R. G. Hoyle, J. D. Castle, N. Leitinger, M. L. Bland
This study shows that Toll signaling in Drosophila fat body shifts lipid metabolism from triglyceride storage to phospholipid synthesis, driven by ER stress and AMP production demands.
bioRxiv · Mar 1, 2020Physiology