Molecular mechanism of plasmid-borne resistance to sulfonamides
M. Venkatesan, M. Fruci, L. A. Verellen, T. Skarina, N. Mesa, P. J. Stogios, A. Savchenko
This study identifies the molecular mechanism of intrinsic sulfonamide resistance in Sul enzymes through structural and functional analyses, revealing a modified active site that confers high resistance without fitness cost.
bioRxiv · Jun 30, 2022Microbiology