TWO CLASSES OF MYOSIN INHIBITORS, BLEBBISTATIN AND MAVACAMTEN, STABILIZE β-CARDIAC MYOSIN IN DIFFERENT STRUCTURAL AND FUNCTIONAL STATES
S. K. Gollapudi, W. Ma, S. Chakravarthy, A. C. Combs, N. Sa, S. Langers, T. C. Irving, S. Nag
This study compares how two myosin inhibitors, mavacamten and blebbistatin, stabilize myosin in distinct structural and functional states, potentially affecting cardiac function differently.
bioRxiv · Dec 19, 2020 · PreprintBiochemistry