W. Ma

Discrimination of Jamaican fruit bat lymphocytes by flow cytometry

The paper identifies cross-reactive monoclonal antibodies for profiling Jamaican fruit bat lymphocytes and generates specific antibodies for CD3γ, CD4, and CD8 to enable flow cytometry analysis of T cells.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

Control of Inflammatory Response by Tissue Microenvironment

This study shows acidic pH regulates macrophage inflammatory responses by altering transcriptional condensates involving BRD4, acting as a negative feedback mechanism.

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

High-throughput Screening of Compounds against Autoluminescent Nonreplicating Mycobacterium tuberculosis under Diverse Conditions

This paper develops an autoluminescent model to assess anti-tuberculosis drugs against nonreplicating M. tuberculosis, showing real-time light output correlates with colony-forming units and reveals drug efficacy differences under anaerobic vs aerobic conditions.

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent manner

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

The paper compares antibody responses from individuals with XBB reinfection and those vaccinated with WSK-V102C, showing the vaccine induces stronger neutralization against SARS-CoV-2 variants including JN.1 and BA.2.87.1.

The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.

This study identifies Pwl2 as a virulence factor in the rice blast fungus that suppresses host immunity by altering the localization of HIPP43.

Distinct SARS-CoV-2 populational immune backgrounds induce divergent RBD evolutionary preferences

The paper compares SARS-CoV-2 variants from China and other countries, finding that Chinese variants have more dispersed RBD mutations with higher ACE2 binding and less immune evasion potential due to a distinct immune background.

Diet-induced changes in metabolism influence immune response and viral shedding dynamics in Jamaican fruit bats

The study shows diet affects viral shedding in Jamaican fruit bats, with suboptimal-sugar diets leading to higher viral RNA shedding than suboptimal-fat diets.

SANTA FE OXA: Self-assembled oxaliplatin nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

This paper investigates how the E525K mutation in beta-cardiac myosin affects actin activation, power stroke, and phosphate release, revealing structural and kinetic changes linked to dilated cardiomyopathy.

Titin-based force regulates cardiac myofilament structures mediating length-dependent activation

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.

Polygonum Cillinerve polysaccharide inhibits Transmissible gastroenteritis virus by regulating microRNA-181

This study shows that Polygonum Cillinerve polysaccharide inhibits TGEV infection by modulating miRNA-181 and reducing apoptosis in PK15 cells.

Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

Biodesign of Frugal CRISPR Kits for Equitable and Accessible Education

This study develops a frugal CRISPR kit for K-12 education, enabling hands-on genome engineering experiments without traditional lab equipment or high costs.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

The phosphorylation landscape of infection-related development by the rice blast fungus

This study maps the phosphorylation landscape of the rice blast fungus during infection, identifying key phosphoproteins and pathways involved in disease progression.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice

This study shows that reduced systemic ketogenesis in fasted mice enhances erythroid maturation by boosting fatty acid synthesis and mevalonate pathway with decreased histone acetylation.

Pathogen protein modularity enables elaborate mimicry of a host phosphatase

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.