Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
H. L. Turner, R. Andrabi, C. A. Cottrell, S. T. Richey, G. Song, S. Callaghan, F. Anzanello, T. J. Moyer, W. Abraham, M. Melo, M. Silva, N. Scaringi, E. G. Rakasz, Q. J. Sattentau, D. J. Irvine, , A. B. Ward
This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.
bioRxiv · Feb 16, 2021Immunology