M. Silva

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

The paper identifies phosphorylation of NEUROGENIN2 as a regulator of human radial glial cell neuronal output, leading to increased production of upper-layer neurons.

Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

TLCellClassifier: Machine Learning Based Cell Classification for Bright-Field Time-Lapse Images

TLCellClassifier improves cell detection, tracking, and classification in time-lapse images using CNN, metric learning, and LSTM, outperforming existing tools in accuracy and efficiency.

High-resolution genomic ancestry reveals mobility in early medieval Europe

This study uses high-resolution genomic ancestry analysis to reveal mobility patterns in early medieval Europe using ancient DNA.

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.

Focusing antibody responses to the fusion peptide in rhesusmacaques

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulations

This study evaluates in vitro methods for predicting eye irritation of agrochemicals, finding they accurately predict non-classified formulations, reducing animal testing needs.

Genomic and ecological factors shaping specialism and generalism across an entire subphylum

The paper analyzes genomic, metabolic, and ecological data from nearly all Saccharomycotina yeast species to show that intrinsic genetic factors, not trade-offs or extrinsic factors, drive variation in niche breadth.

Serialized On-grid Lift-In Sectioning for Tomography (SOLIST)

The paper introduces SOLIST, a method that improves cryo-electron tomography by increasing throughput, reducing ice contamination, and enhancing sample stability for various specimens.

Small molecule screen identifies non-catalytic USP3 chemical handle

The paper identifies a small molecule ligand for the ZnF-UBD of USP3 with a KD of 14 µM, which could serve as a starting point for developing DUBTACs.

Loading-Induced Bone Formation is Mediated by Wnt1 Induction in Osteoblast-Lineage Cells

This study shows that Wnt1 in osteoblast-lineage cells mediates bone formation in response to mechanical loading in mice.

Resistance to EGFR inhibitors in lung cancer occurs through horizontal transfer and is associated with increased caveolins expression

Yersinia pestis genomes reveal plague in Britain 4,000 years ago

The paper identifies Yersinia pestis genomes from 4,000-year-old British remains, showing plague in Britain earlier than previously documented.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

Fracture healing is delayed in the absence of gasdermin signaling

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

Intestinal Gluconeogenesis Regulates Brown and White Adipose Tissues Functions in mice

This study shows that intestinal gluconeogenesis regulates adipose tissue metabolism in mice, reducing adiposity and enhancing thermogenesis under a high-calorie diet.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

Metabolic independence drives gut microbialcolonization and resilience in health and disease

This study investigates how metabolic independence influences gut microbial colonization and resilience in health and disease using fecal microbiota transplantation.

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells

This study identifies immune cell states in pancreatic cancer, showing regulatory T-cells and dysfunctional CD8+ T-cells contribute to a suppressive microenvironment, suggesting new therapeutic targets.

Macrofaunal Diversity and Community Structure of the DeSoto Canyon and Adjacent Slope

The paper examines macrofaunal diversity and community structure in the DeSoto Canyon and adjacent slope, finding depth-related patterns and habitat-specific differences influenced by environmental factors.

LRP5-deficiency in OsxCreERT2 mice models intervertebral disc degeneration by aging and compression

This study shows that LRP5-deficiency in osterix-expressing cells leads to intervertebral disc degeneration, reduced WNT signaling, and decreased expression of key markers in aged and compressed discs.

A ciliary BBSome-ARL-6-PDE6D pathway trafficks RAB-28, a negative regulator of extracellular vesicle biogenesis

This study identifies a ciliary pathway involving RAB28, BBSome, and PDE6D that regulates extracellular vesicle biogenesis and homeostasis in C. elegans sensory organs.

A different gut microbiome linked to inflammation found in cirrhotic patients with and without hepatocellular carcinoma

The paper compares gut microbiomes in cirrhotic patients with and without hepatocellular carcinoma, finding inflammatory-associated microbial patterns linked to HCC.