M. Melo

Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons

This paper uses machine learning to design cytotoxic T cell epitopes by modeling proteasomal degradation scores and testing their immunogenicity.

Evolution of immune genes in island birds: reduction in population sizes can explain island syndrome

This study investigates immune gene evolution in island birds, finding demographic effects reduce genetic diversity and selection efficacy, but relaxed selection due to reduced parasite pressure is only evident in some immune gene categories.

Genomic signatures of isolation, hybridization, and selection during speciation of island finches

This study examines genomic signatures of isolation, hybridization, and selection in sympatric island finches, revealing complex speciation dynamics involving genetic drift, introgression, and natural selection.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.

Cytoskeletal tension actively sustains the migratory T cell synaptic contact

This study identifies a mechanical mechanism involving cytoskeletal tension that sustains T cell-APC synaptic contact symmetry and stability.